Bulk biosensing assays often miss crucial information, especially about rare biomarkers masked within complex clinical samples. We're designing a solid-state nanopore-based platform, to detect disease-specific biomarkers in a rapid, ultrasensitive, high-throughput manner. This single-molecule sensing approach provides unprecedented detail about a sample's composition, including identifying and quantifying low-abundance biomarkers. This approach enables highly multiplexed, ultrasensitive, label-free, and amplification-free biomarker detection, fundamentally advancing clinical diagnostics.